Dioxins Exposure and the Risk of Breast Cancer: A Systematic Review and Meta-Analysis

Context: Dioxins and dioxin-like chemicals composed of 419 compounds are a large group compounds, including polychlorinated di-benzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyls (PCBs). extremely persistent in the environment disperse great distance from emission source, bioaccumulation food chain is one their critical properties. The incidence breast cancer among Iranian women about 30 to 35 per 100,000 cases. present study systematic review published studies English language discover relationship between exposure dioxin cancer. Methods: We conducted comprehensive literature utilizing PubMed, Embase, Scopus, ISI web science databases. MeSH-based keywords used included Organic Chemical (MeSH) OR AND Breast disease (MeSH). Results: indicated significant positive association dioxins risk Only study, mortality rate was reported terms dioxins, standardized rates (SMRs) were determined. Conclusions: Although there limitations this statistical analyses various epidemiological demonstrated that linked an increased